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3.4 Mechanisms of ferroptosis in traumatic brain injury TBI is commonly caused by external trauma (Figure 3C), and its stages of damage are like those of SCI, including primary irreversible mechanical damage and secondary injuries (Maas et al., 2022)

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Genetic ablation of Gli3 in MuSCs induces increased expression of HH target genes ( Gli1 and Ptch1 ), cell size, mitochondrial activity, and mTORC1 signaling, inducing G Alert transition to elevate proliferation at the expense of early differentiation [100]

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