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Oxidative stress and endothelial dysfunction Many disorders, such as hypertension, atherosclerosis, dyslipidemia, diabetes mellitus, CVD, renal failure, and ischemiareperfusion damage, are primarily caused by endothelial dysfunction and oxidative stress
Retrieved from O'Neill, E.S., Wiegmann, A.L., Parrella, N., et al
Similar to liraglutide, semaglutide (Novo Nordisk) is a fatty-acylated GLP-1 analogue with a stearic-diacid at lysine position 20, linked via a di-aminoethoxy, -glutamic acid spacer, and an aminoisobutyric residue at position 2 to provide protection from DPP-IV degradation [28]
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