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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

However, popularity should not be mistaken for universal necessity or zero risk

Side effects and injection-site reactions: the real incidence data Aggregated side effect reports from 1,200+ patient reviews and compounding pharmacy adverse-event logs: Injection-site soreness is the dominant complaint

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