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Dose adjustments are based on: individual tolerance appetite response weight loss progress metabolic health goals Gradual adjustments help reduce the likelihood of nausea or digestive discomfort

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Nociceptive pain reflects the normal functioning of the somatosensory systems responding in a stimulus-dependent manner to an actual or potential damage of non-neuronal tissue and is treated with conventional non-steroidal anti-inflammatory and/or opioid analgesics (Scholz et al., 2019)