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Conversely, LEAP2-deficient mice exhibited decreases in energy expenditure and increases in food intake, body weight, lean mass, hepatic fat accumulation, and body length in HFD female mice, but has no biologically significant effects on those parameters in HFD male mice or standard chow-fed female and male mice (145)
NHS England is developing more specific guidance on clinical prioritisation in early 2025 in preparation for implementing this programme
Pricing, dosage and treatment duration depend on the providers evaluation and individualized prescription
