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Whats more, most of them indicate that the supplement can cause a small amount of weight loss ( On average, garcinia cambogia has been shown to cause weight loss of about 2 pounds (0.88 kg) more than a placebo, over a period of 212 weeks ( For example, the largest study in 135 people did not find any difference in weight loss between those taking garcinia cambogia and the placebo group ( As you can see, the evidence is mixed

Recheck at 8 weeks and every 12 weeks thereafter

Some risks, however, are known

Homocysteine, through activation of NMDA receptors, induces Ca +2 , leading to excitotoxicity, astrocyte activation with release inflammatory mediators, and matrix metalloproteinase (MMP) activation with subsequent BBB injury and microvascular inflammation (Kamat et al