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Since polyphenols can act as PAINS in biochemical assays (autofluorescence, redox cycling, aggregation, metal chelation), in-vitro hits without orthogonal validation were downgraded
By integrating real-time hormonal lab results, genetic markers, and reported side effect data, an AI model could help predict a patient's sensitivity to the medications and potentially recommend a slower, more cautious titration schedule or a lower maintenance dose from the start, minimizing discontinuation rates and improving adherence
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