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Those are meaningful wins
The drugs mimic a gut hormone called glucagon-like peptide 1, which acts on the brain to dampen appetite, in addition to controlling blood sugar levels
Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)
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