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Novo Nordisk already sells Rybelsus, which is approved to treat diabetes and is an oral version of semaglutide, the same medication used in the diabetes drug Ozempic and Wegovy
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Mechanistically, E2F1-mediated CHAC1 upregulation promotes PKM2 SUMOylation enabling PKM2 nuclear translocation or kinase activation ( CHAC1s contribution to tumor progression is markedly influenced by the cellular and tumor context, differing across various cancer types
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