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As a general rule, 0.2 to 0.4 units of insulin per kilogram of body weight can be used to calculate the initial total daily insulin dose in insulin nave patients with type 1 diabetes

Fix: Start with 2030 mcg/day and assess tolerance over 12 weeks

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GLP-1 receptor agonists also increase intestinal fluid secretion through chloride channel activation, as described in preclinical and clinical motility studies