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Although hydration doesn't directly increase GLP-1 production, it supports healthy digestion, helps regulate appetite, and promotes overall metabolic function

Forner-Piquer I, Klement W, Gangarossa G, Zub E, De Bock F, Blaquire M, Maurice T, Audinat E, Faucherre A, Lasserre F, Ellero-Simatos S (2021) Varying modalities of perinatal exposure to a pesticide cocktail elicit neurological adaptations in mice and zebrafish

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The researchers found that randomization to GLP-1 RA treatment among all included trials was associated with increased risks for gallbladder or biliary diseases (pooled relative risk [RR], 1.37), specifically cholelithiasis, cholecystitis, and biliary disease (RRs, 1.27, 1.36, and 1.55, respectively)