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Evidence-Based Clinical Research A large proportion of the adult population in the UK is now experiencing excess body weight, and this number continues to rise year after year

Additionally, obesity is associated with insulin resistance, chronic inflammation, and hypothalamic-pituitary-gonadal axis dysfunction, all of which can suppress testosterone production

The STEP clinical trial program, which evaluated higher doses of semaglutide (2.4 mg weekly) for chronic weight management, demonstrated significantly higher rates of vomiting, with approximately 20-25% of participants reporting this adverse effect during the study period