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The apparent Michaelis-Mentes constant (K m ), maximum velocity for the enzyme preparation (V max ) and specific activity of the enzyme fraction obtained from the plot were 6.83 M, 0.46 nmoles ml reaction mixture-1 min -1 and 0.34 nmoles g protein -1 min -1

For targets with no existing fluorophore conjugated antibody the following primary antibodies were used: anti NRF2 polyclonal (1:200, Thermofisher, PA5-27882)

Resistance after CF-based NAC may be driven predominantly by the selection or enrichment of pre-existing resistant subclones or cell states, rather than by extensive therapy-induced reprogramming

Each lot of BPC-157 + TB-500 is independently tested