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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, a class of medications designed to mimic the action of the naturally occurring hormone GLP-1
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A change in diabetes drug prescribing led to clinical trials of intranasal insulin administration, followed by insulin sensitizers, including metformin and peroxisome proliferator-activated receptor agonists, followed by incretin mimetics targeting primarily GLP-1R (GLP-1RAs) [106]
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