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For example, the glutathione conjugate of hexachlorobutadiene is processed in the kidneys into reactive intermediates, leading to nephrotoxicity
It also works as an antagonist to opiate receptors which makes it useful in treating alcohol/opiate withdrawal syndrome
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Curr Med Res Opin 2004;20:1377-84
Stock solutions of test compounds that are water soluble were made up at 20 times the final assay concentration in buffer (including glucose, GEP44, GEP12, exendin-4, PYY 1-36 and insulin)
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