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The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)
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The GLP1R Gene: The Receptor That Receives the Signal The lock that GLP-1 must open Imagine GLP-1 as a key and the GLP-1 receptor as the lock
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