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However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems

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Building on these findings, clinical trials are now investigating these therapeutic applications more systematically, including studies examining incretin agonists for both alcohol consumption and alcohol-related disorders (ClinicalTrials.gov identifiers: NCT06546384, NCT06409130, NCT07046819, NCT05891587, NCT05895643, NCT06015893, NCT05892432, NCT06939088, NCT06727331, and NCT06994338)