when switching from semaglutide to tirzepatide Can you switch from Wegovy

The increase in active GLP-1 levels helps to improve glycemic control and insulin secretion (Ellingsgaard et al., 2020)

effectively uh basically buying them sort of off the shelf and illegally per se through online sources well what's the issue with that well according to a twenty twenty four study the actual purity of some of these compounds is anywhere from 7.7 to 14.3 percent in this sample from this this study uh that's definitely concerning because you can see that if you're not getting the right dose you could have adverse effects or you may try to take more right well the other other issues patients have tried other medications like say or excuse me supplements like berberine we talked about this in our second video berberine helps with the insulin response it can help a lower blood sugar some people say it's sort of like the natural glp but it really isn't it acts on a different completely different pathway and so what patients sometimes will do is double up they'll they'll have berberine or this gray market glp or the gray market glp is just berberine right and so they don't really know what they're getting and that's the issue with not having that regulation and and inspection so what does this mean well poison control calls over the last several years are up over one thousand percent uh related to complications from GLP, particularly injections and mixing

Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P4502B1 and NADPH-cytochrome P450 reductase Arch Biochem Biophys 1993

What human data say so far (and what they dont): Early Clinical Signals of GLP-1 and Hormone Therapy Synergy The biological rationale for combining HRT and GLP-1 receptor agonists is, as the preceding sections have established, mechanistically coherent