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The new drug is in its early trial stage before being cleared for use
The consequent low production of BLIMP-1 decreases plasma cell differentiation and antibody production, which mirrors the effect of increased ROS on splenic B cells observed both with and without G6PD inhibition 137,138,139,140 (Fig
Moreover, the SELECT study showed that semaglutide significantly reduced the incidence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke (hazard ratio 0.80) ( 6 Practical issues when prescribing GLP-1RA in T1D GLP-1RA are not currently approved for treatment of T1D, but they may still be covered by insurance if prescribed to treat obesity in these patients (although insurance coverage for obesity remains limited)
