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Endocrine and Metabolic Pathway Investigations : Investigated how changes in activin-linked signaling relate to endocrine readouts in preclinical systems (mechanistic work only)
That made them a logical group of drugs to study in breast cancer populations, especially because preclinical work has suggested possible anticancer effects and because weight reduction itself may influence long-term outcomes
In order to obtain any reliable read-out in reasonable time, a low molecular redox mediator is almost regularly required to enable an electron transfer between the macromolecule and the electrode and, of course, access of oxygen has to be strictly prevented
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