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Do not use orlistat if you have had an organ transplant because the medicine interferes with the medicines used to prevent transplant rejection

[9] Important safety considerations include monitoring for signs of acute pancreatitis (severe, persistent abdominal pain, sometimes with vomiting) which requires urgent medical assessment, and potential worsening of diabetic retinopathy, particularly in patients with pre-existing retinopathy experiencing rapid improvement in blood glucose control

However, further research is needed to confirm that the improvements in systemic inflammation and joint symptoms observed with these therapies are also tied to improvements in joint inflammation.

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