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GLP-1 receptors are expressed throughout the brain, and preclinical evidence indicates that GLP-1 receptor agonists can reduce neuronal damage, improve synaptic function, and counter oxidative stress

MC1R activation in melanocyte models stimulates eumelanin synthesis via the cAMPPKAMITF signalling axis

While the medication itself doesn't directly form gallstones, its potent weight loss effects create conditions that increase gallbladder disease risk

BAT regulates energy expenditure through a process known as adaptive thermogenesis, in which uncoupling protein-1 (UCP1, a BAT marker) uncouples mitochondria respiration to generate heat instead of adenosine triphosphate [7]