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Safety Although the studies included in this review identified no important safety issues, orally administered l-carnitine supplementation has been linked to a increase in trimethylamine (TMA) and trimethylamine- N -oxide (TMAO), as unabsorbed carnitine is metabolised by the gut microbiota to TMA and later oxidised to TMAO in the liver

Treatment should be based on the combined symptom pattern, laboratory findings, previous nutrient reactions, medications, diet and clinical stability

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GST mediated detoxification is critical for adaptation against xenobiotics including plant allelochemicals and synthesized pesticides