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Timing: Evening or bedtime administration may align with natural GH secretion patterns [4]

[1] [3] The standard UK treatment involves hydroxocobalamin 1mg intramuscular injections, with dosing regimens typically consisting of initial loading doses (e.g., every other day for two weeks) followed by maintenance doses every 2-3 months for conditions like pernicious anaemia

This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates

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