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Figure 5 A pivotal finding highlighted in this review is the initiation of a multi-faceted pathological cascade in the testicular microenvironment by varicocele-induced venous congestion: elevated local temperature, hypoxia, and metabolic waste accumulation trigger immune cell infiltration and activation, leading to the overproduction of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and ROS
doi: 10.1016/j.bcp.2020.114187 147 CapehornMSCatarigAMFurbergJKJanezAPriceHCTadayonSet al
Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3-E3 ubiquitin ligase-dependent pathway
It has been shown that lower densities prime cells for hemolysis and eryptosis [398]
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