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Tirzepatide provides greater weight loss and improved sugar control compared to semaglutide, while semaglutide offers proven cardiovascular benefits
The ChEMBL drug registry records tirzepatide at maximum phase 4 (approved), first approval 2022, parenteral, with a first-in-class GIP-agonist designation and a boxed-warning flag
Underhill TJ, Greene MK, Dove AF
As a result, some are able to achieve glucose and weight reductions comparable to injectable semaglutide therapy, while others struggle with missed doses and dosing with other medications or food and drink, and thus suboptimal benefits
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