glp-1 and cancer risk GLP-1s tied to lower for 10 types of compared with insulin in type 2 diabetes The effect of GLP-1R agonists

Amid the vinyl records and typewriters, scientists were puzzling over a strange quirk in human biology called the incretin effect

Acta 1783 , 629640 (2008)

This has been demonstrated in multiple studies with rats and swine, where growth hormone levels significantly increased after injections without impacting ACTH and cortisol plasma levels: In pentobarbital anaesthetised rats, ipamorelin released GH with a potency and efficacy comparable to GHRP-6 (ED50 = 80+/-42nmol/kg and Emax = 1545+/-250ng GH/ml vs 115+/-36nmol/kg and 1167+/-120ng GH/ml)

A post-hoc analysis of this trial revealed that tirzepatide users experienced an amelioration of the atherogenic lipoprotein profile with reduction in large triglyceride rich lipid particles, small low-density lipoprotein particles (LDLP) and apolipoprotein B, consistent with the significant improvement of insulin sensitivity