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After control for confounding, the hazard ratio for self-harm was around the null value (1.03, 95% CI 0.70 to 1.51), and those for suicidal ideation and suicide were under the null value but with wide confidence intervals (0.84 (0.65 to 1.08) and (0.14 (0.02 to 1.31)), respectively (table 6)

Lifestyle interventions being used

Genome-wide association studies have identified numerous AD risk genes enriched in microglia and immune pathways, and longitudinal studies demonstrate that neuroinflammatory biomarkers predict cognitive decline 3,4

Clinical trials showed modest results, and AOD-9604 was not pursued through full FDA drug approval