With the approval of Wegovy for MASH, we provide a new treatment to people living with MASH that not only halts the disease activity but helps reverse the damage caused to the liver. As of today, Wegovy is available in the US for the treatment for MASH
Standard clinical dose escalation The FDA-approved Mounjaro (brand tirzepatide) follows this schedule: Weeks 1-4: 2.5 mg once weekly (starting dose, allows GI adaptation) Weeks 5-8: 5 mg once weekly (first therapeutic dose increase) Weeks 9-12: 7.5 mg once weekly (if tolerated and additional effect needed) Weeks 13-16: 10 mg once weekly (continued escalation) Weeks 17-20: 12.5 mg once weekly (approaching maximum) Week 21+: 15 mg once weekly (maximum approved dose) Each dose is maintained for at least four weeks before escalation
Carnitine analogs produced by the gut microbiota can colocalize with carnitine in the white matter of the brain and inhibit carnitine-mediated FAO in cell culture models of mouse CNS white matter, affecting the hosts nervous system, which provides a new perspective for understanding the complexity of the gutbrain axis [252]
Natural GLP-1 Support: Fiber, SCFAs, Akkermansia & Prebiotics What youll learn: Evidence-based strategies to support natural GLP-1 physiology through fiber, resistant starch, polyphenols, and beneficial microbes like Akkermansia
