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Semaglutide is approved in the UK by the MHRA (MHRA Semaglutide SmPC) and is recommended by NICE (Technology Appraisal TA875) for use within specialist NHS weight management services

In this double-blind trial of 1,961 adults with a body mass index (BMI) of 30 or higher, adults on high dose 2.4 mg of weekly semaglutide (compared with the usual type 2 diabetes dose of 0.5mg or 1mg) lost an average 14.9% of baseline body weight after 68 weeks of treatment versus only 2.4% for a group on placebo and lifestyle intervention alone

A "One-Health" Study on Human-Animal Interaction in a Region with a High Prevalence of Obesity