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This phase II clinical trial provided some evidence of benefit on decline in the ALSFRS-R and used a combination of agents to tackle several pathophysiological disease mechanisms
Weight loss with GLP-1s is typically gradual
This guide covers the actual clinical data on lean mass loss, why those numbers hit differently for trained lifters, how GLP-1 drugs interact with muscle biology at a mechanistic level, whether the loss is disproportionate or just expected physiology, and how to adapt both your training and your nutrition to change the outcome
Given the benefits of this class of medication, it is likely more approvals for more indications will be on the horizon
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