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The frequencies of event adjudication committee-confirmed events, including acute kidney injury, cardiovascular events and malignant neoplasms, were low and similar across all treatment arms in the overall population (ESM Table 4)

Once cocaine taking was extinguished, rats were pretreated with vehicle or exendin-4 (2.0 g/kg, i.p.) 10 minutes prior to a priming injection of cocaine (10 mg/kg, i.p.)