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The same principles that guide peptide dosing strategies across multiple compounds apply here: start low, increase slowly, and pay attention to response rather than rushing to an arbitrary target dose
According to the National Institute of Diabetes and Digestive and Kidney Diseases, GLP-1 receptor agonists carry warnings related to thyroid C-cell tumors observed in rodents, though this effect has not been clearly demonstrated in humans
If oral GLP-1s are able to engage patients who were previously unwilling or unable to initiate injectable therapy, expectations for oral uptake may need to be reconsidered
An animal study showed bone loss associated with oxidative stress in ovariectomized mice compared to healthy controls [20]
