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An increased risk of lower extremity amputation was observed in CANVAS and a few real-world studies, but not in CREDENCE 54 , 55 , 84 , suggesting that this is no longer a major concern
Lower temperatures slow molecular motion, which in turn reduces the rate of degradation reactions
A standard multivitamin within RDA limits may be considered if dietary intake is insufficient, but supplements should ideally target confirmed deficiencies identified through blood tests
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