found that in a small cohort of PASC patients, increases in medium- and long-chain acylcarnitines were among the most pronounced changes in a plasma metabolomic experiment between healthy controls and patients with PASC [48]
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101,102 ME2 depletion, accompanied by an increased NADP + /NADPH ratio and ROS levels, impacts PI3K/AKT signaling and enhances the sensitivity of erythroleukemia and NSCLC cells to cisplatin