Acute ischemia by a variety of mechanisms, including stimulation of N -methyl-d-aspartate (NMDA) receptors, mitochondrial dysfunction, activation of neuronal nitrite oxidase (NOS), induction of NOS by cyclooxygenase 2, autooxidation of catecholamines, and metabolism of free fatty acid such as arachidonic acid can increase the production of free radicals [38, 39]
Fralick, M., Colacci, M., Odutayo, A., Siemieniuk, R., & Glynn, R
Journal of Neuroscience Research 92 (4): 446-54
Their depression improves in ways that seem to go beyond what youd expect from weight loss or appetite suppression alone