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They are not indicated for type 1 diabetes, should not be used with DPP-4 inhibitors, and require caution in patients with pancreatitis history or diabetic retinopathy
In type II diabetes, the number of docked granules is about 1/3 lower than in normal cells, and the rate of glucose-stimulated exocytosis is only 20% of that in normal cells (Kwan and Gaisano, 2005)
Subsequently, the -oxidation metabolites increased, the -oxidation metabolites decreased and 4-en-valproate was no longer detected in urine
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