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Unlike corticosteroids or broad immunosuppressants, KPV does not appear to suppress immune function globally its NF-kB inhibition is targeted and does not eliminate the immune response, only attenuates the pro-inflammatory cascade
Systematic site rotation also reduces the risk of localised lipodystrophy (changes in fat distribution) and the development of persistent lumps or subcutaneous nodules at frequently used injection points
It upregulates genes involved in repair, antioxidant defense, and stem cell function while downregulating genes associated with inflammation, fibrosis, and tissue destruction
Highlights of prescribing information: Zepbound (tirzepatide) injection, for subcutaneous use
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