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For glycemic outcomes, the distribution of absolute HbA1c changes showed greater reductions for GLP-1 users compared to metformin users, as seen in Figure 2

Why Many Patients Interested in Future Therapies May Already Have Higher Health Risks It is important to recognise that many individuals researching emerging weight-management treatments may already have underlying risk factors such as: obesity or metabolic syndrome type 2 diabetes high blood pressure elevated cholesterol sleep apnoea These conditions increase cardiovascular risk independently of any treatment