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No published research characterizes adverse events at sustained injectable doses above 5-10 mg/week in humans

At the 15mg dose, participants lost an average of 52 pounds

Despite these limitations, the study provides preclinical evidence demonstrating that CoQ10 preserves CYP3A1 activity and mitigates ATO-induced hepatotoxicity, offering a foundation for future mechanistic, pharmacokinetic, and translational studies to improve statin safety

Special population studies, including evaluation in elderly patients, patients with significant comorbidities, and patients with organ dysfunction, would help establish safety profiles for diverse clinical populations