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To enable the discovery of novel GLP-1R G-protein-biased agonists displaying selectivity and high potency for the GLP-1R, combinatorial peptide libraries were designed based on the competitive GLP-1R antagonist Ex 939 sequence to which 710 random amino acids have been added to the N terminus
H., Nexo, E., McNulty, H., Refsum, H., Gueant, L., Dib, J., Ward, M., Murphy, M., Green, R., Ahmadi, K