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The liver is tasked with processing lipophilic (fat-soluble) environmental toxins, pharmaceutical drugs, and metabolic waste products into hydrophilic (water-soluble) compounds that can be safely excreted via urine or bile
It uses a methyl group donated by S-adenosylmethionine (SAM) to methylate nicotinamide a vitamin B3 form that would otherwise be recycled back into NAD+
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The lipid tail allows retatrutide to bind serum albumin, which slows clearance and gives the peptide a half-life long enough for once-weekly dosing in published animal pharmacokinetic work
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