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Fish Physiol Biochem

GLP-1 medications cannot be legally purchased over the counter in the United Statesthey are controlled prescription drugs requiring medical evaluation and ongoing monitoring

At the same time, the availability of Medicares lower negotiated price for certain GLP-1 products under the Medicare Drug Price Negotiation Program (semaglutide beginning in 2027 and dulaglutide beginning in 2028) could mitigate the increase in Medicare spending that could come about from ongoing and expanded use of these medications

A longstanding unmet need in the care of T2DM and obesity has been to identify therapies that deliver effective glycemic control and clinically meaningful weight loss without increasing cardiovascular risk or severe hypoglycemia