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When insulin sensitivity improves, your body can use glucose for energy rather than storing it as fat

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On April 1, 2026, the FDA approved orforglirpon under the brand name Foundayo to reduce excess body weight and maintain weight reduction long term in: Adults with obesity Adults with overweight and at least one weight-related medical condition Like other GLP-1s for weight loss, orforglipron is also indicated in combination with a reduced-calorie diet and increased physical activity

The mechanism works the same way whether a patient has elevated blood sugar or maintains normal glucose levels, making these drugs equally relevant for weight management across metabolic profiles