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In both trials, during the 10-day treatment period, subjects should not have consumed alcohol, liquids or food containing poppy seeds, grapefruit (dosing conditions trial), caffeine or other xanthines, changed their exercise pattern or daily routines (dosing conditions trial) or performed strenuous physical exercise (food-effect trial)

it should not be restarted if pancreatitis is confirmed Symptoms of gallbladder problems , such as upper right abdominal pain, fever, or jaundice (yellowing of the skin or eyes) A lump or swelling in the neck , hoarseness, or difficulty swallowing, which could indicate thyroid abnormalities seek specialist advice Symptoms of low blood sugar (hypoglycaemia) if also taking insulin or a sulfonylurea, such as shakiness, sweating, confusion, or palpitations A notable or sustained increase in heart rate without an obvious cause Significant changes to your menstrual cycle or unexpected symptoms that may relate to reproductive health Use NHS 111 (online at 111.nhs.uk or by telephone) when you need urgent medical advice and your GP or trial team is not immediately available

Always date-label vials at reconstitution and discard after the applicable window

59 Importantly, GSH mediates regulatory S-glutathionylation of proteins