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A small retrospective analysis from 2024 suggested modest additional weight loss (13% more) when topiramate was added to semaglutide in patients who had plateaued, but the effect was inconsistent and accompanied by higher adverse-event rates in 40% of participants
Potential candidates include people interested in improving mitochondrial function, supporting cognitive performance, or optimizing metabolic health
Predicting Side Effects and Setting Expectations Adam and his team also looked at whether genetic variants could explain why some people experience more side effects than others
195 Histones also serve as acceptors of ADP-ribose upon DNA damage to initiate DNA repair
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