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Increased risk of depression or thoughts of suicide
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Apart from maintaining calcium channel homeostasis, GLP-1RAs also activate ATP-sensitive potassium channels to attenuate cardiac apoptosis and hypertrophy induced by pressure overload [166]
Taking berberine alongside metformin, insulin, or sulfonylureas such as gliclazide is not recommended without medical supervision, as the combination may cause additive blood glucose-lowering effects and increase the risk of hypoglycaemia
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