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The molecule contains a cysteine-linked disulfide bridge that constrains the peptide into a cyclic conformation, an important feature for maintaining its signaling profile in biochemical and adipocyte-based assays

Needle size, for example, is exceedingly small, making subcutaneous administration at home relatively painless compared to larger needle gauges used with thicker medications for things like blood draws

doi: 10.1016/J.BBAGEN.2011.04.016 37 ProudfootJMMurreyMWMcLeanSGreenlandELBardenAECroftKDet al

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