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The quality of evidence varies because PRP preparation methods differ between providers, making it hard to compare studies directly

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Singly-housed rodents may have increased adiposity 101 and, moreover, singly-housed mice in standard caging can engage in coprophagy of their own feces that may impact their cecal microbiome 102

As progress is made, the frequency might be adjusted to bi-weekly or monthly to maintain consistent energy levels and support ongoing metabolic function