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These include redness, swelling, tenderness, itching, bruising, and occasionally a small lump or bump under the skin that may persist for several days
In research they are studied for their interaction with the growth-hormone-axis signalling pathway
Receptor Downregulation Findings and Study Design Implications A well-documented finding in the research literature is that continuous IGF-1 receptor activation leads to receptor downregulation after approximately four to six weeks, reducing cellular responsiveness to further stimulation
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